PIP5K1C Antibody (YA6704)
(Synonyms: Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; PtdIns(4)P 5 kinase gamma antibody; PtdIns(4)P-5-kinase 1 gamma antibody; Type I P; IP : kinase antibody; )PIP5K1C Antibody (YA6704) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
PIP5K1C Antibody (YA6704) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PIP5K1C.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 87/90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 73 kDa
Recombinant protein within human PIP5K1C aa 31-470 / 668.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PIP5K1C encodes phosphatidylinositol-4-phosphate 5-kinase type 1γ (PIPKIγ), a lipid kinase that catalyzes the conversion of phosphatidylinositol 4-phosphate into phosphatidylinositol 4, 5-bisphosphate (PIP2), a key second messenger regulating signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility[1][2]. Mechanistically, PIP5K1C organizes localized PIP2 pools at focal adhesions and other membrane-associated signaling domains, thereby coordinating integrin-mediated adhesion and cytoskeletal remodeling[3][1]. Through direct association with talin, PIPKIγ is recruited to focal adhesions, where it promotes integrin-talin coupling and regulates focal adhesion assembly and turnover[3][1][4]. In addition to its adhesion-related functions, PIP5K1C contributes to clathrin-dependent endocytosis, synaptic vesicle trafficking, and directional cell migration, highlighting its central role in membrane dynamics and cellular signaling[1][2]. Disease studies further demonstrate that altered PIP5K1C activity influences tumor-associated signaling pathways, including AKT-STAT3 signaling and cancer cell invasion, while genetic deficiency causes developmental abnormalities and tissue-specific defects in experimental models[4][5]. Compared with the related isoforms PIP5K1A and PIP5K1B, PIP5K1C exhibits distinctive localization to focal adhesions and specialized interactions with talin, supporting nonredundant functions in adhesion-dependent signaling and migration[3][1][4]. Although PIP5K1C remains an attractive therapeutic target, selective pharmacological modulators are currently less established than those available for other lipid signaling enzymes, making genetic and mechanistic approaches the primary tools for experimental investigation[4][5].
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Subcellular Localization
Cell membrane,Endomembrane system,Cytoplasm,Cell junction, focal adhesion,Cell junction, adherens junction,Cell projection, ruffle membrane,Cell projection, phagocytic cup,Cell projection, uropodium,Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Isoform 1 is strongly expressed in brain and also detected in heart and lung|Isoform 2 is strongly expressed in pancreas and liver and in lesser quantities in brain, heart, lung and kidney|Isoform 3 is detected in large amounts in heart and large intestine, is also present in lung, pancreas and thyroid, and to a lesser extent in brain, stomach and kidney -
Isoforms & Post-Translational Modification
O60331 has four isomers: O60331-1: 73260 Da (predicted); O60331-2: 76620 Da (predicted); O60331-3: 77484 Da (predicted); O60331-4: 70214 Da (predicted).
Phosphorylation on Ser-650 negatively regulates binding to TLN2 and is strongly stimulated in mitosis丨Acetylation at Lys-265 and Lys-268 seems to decrease lipid 1-phosphatidylinositol-4-phosphate 5-kinase activity -
Subunit
Interacts with TLN1 (By similarity)
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SwissProt ID
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Synonyms
Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; Diphosphoinositide kinase antibody; LCCS3 antibody; Phosphatidylinositol-4-phosphate 5-kinase type I gamma antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma antibody; PI51C antibody; PI51C_HUMAN antibody; PIP5K GAMMA antibody; PIP5K1-gamma antibody; Pip5k1c antibody; PIP5KIgamma antibody; PtdIns(4)P 5 kinase gamma antibody; PtdIns(4)P-5-kinase 1 gamma antibody; Type I P; IP : kinase antibody;
Documentation
References
[1]. Ling K, et al. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 2002 Nov 7;420(6911):89-93. [Content Brief]
[2]. Uniprotkb.
[3]. Di Paolo G, et al. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature. 2002 Nov;420(6911):85-89. [Content Brief]
[4]. PIP5K1C gene information from NCBI.
[5]. Yan Q, et al. Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling. J Biol Chem. 2022 Mar;298(3):101639. [Content Brief]
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