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PPM1B Antibody (YA9966) (PBS Only)

(Synonyms: PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX)

PPM1B Antibody (YA9966) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PPM1B.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • PPM1B Antibody (YA9966) (PBS Only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:1000-2000 1:150-200

Product Details

Description

PPM1B Antibody (YA9966) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PPM1B.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 52.5 kDa
Immunogen

Full length human recombinant protein of human PPM1B produced in HEK293 cell.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2a

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PPM1B is an Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB

  • Subcellular Localization

    Cytoplasm, cytosol; Membrane

  • Expression


    Tissue_Specificity: Highly expressed in heart and skeletal muscle.

  • Isoforms & Post-Translational Modification

    PPM1B has 5 isoforms, O75688-1: amino acid length is 479, molecular weight is 52643 Da (predicted); O75688-2: amino acid length is 387, molecular weight is 42771 Da (predicted); O75688-3: amino acid length is 192, molecular weight is 20753 Da (predicted); O75688-4: amino acid length is 380, molecular weight is 42086 Da (predicted); O75688-5: amino acid length is 327, molecular weight is 36313 Da (predicted).ISG 化对其活性具有负调控作用PPM1B 存在 5 个异构体，O75688-1：氨基酸个数为 479 个，分子量为 52643 Da (预测)；O75688-2：氨基酸个数为 387 个，分子量为 42771 Da (预测)；O75688-3：氨基酸个数为 192 个，分子量为 20753 Da (预测)；O75688-4：氨基酸个数为 380 个，分子量为 42086 Da (预测)；O75688-5：氨基酸个数为 327 个，分子量为 36313 Da (预测)。Isgylation negatively regulates its activity

  • Subunit

    Monomer (By similarity).

  • SwissProt ID

    O75688

  • Synonyms

    PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX

PPM1B Antibody (YA9966) (PBS Only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PPM1B Antibody (YA9966) (PBS Only) Product Image