VHL Antibody (YA683)
VHL Antibody (YA683) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to VHL.
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Host:
Mouse
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in 1*PBS, 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:500 |
Product Details
VHL Antibody (YA683) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to VHL.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 24 kDa
Synthesized peptide derived from human pVHL
Endogenous
Immunogen affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*PBS, 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272)
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Subcellular Localization
Cytoplasm; Cell membrane; Peripheral membrane protein; Endoplasmic reticulum; Nucleus; Cytoplasm; Nucleus
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Expression
Tissue_specificity:It is expressed in both the human brain and kidneys. -
Isoforms & Post-Translational Modification
P40337 has 3 isomers: P40337-1: 24153 Da (predicted); P40337-2: 19654 Da (predicted); P40337-3: 18532 Da (predicted).
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Subunit
Component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins.
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SwissProt ID
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Research Field
Cell Biology
Documentation
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