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RAIDD Antibody (YA1815)

(Synonyms: CRADD; MGC9163; RAIDD; Death adaptor molecule RAIDD; Death domain containing protein CRADD)
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RAIDD Antibody (YA1815) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAIDD.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IP

  • Reactivity :

    Human

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • RAIDD Antibody (YA1815) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:20

Product Details

Description

RAIDD Antibody (YA1815) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAIDD.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 23 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 23 kDa
Species Reactivity Database

Entrez Gene: 8738 Human

SwissProt: P78560 Human

Immunogen

A synthetic peptide of human RAIDD

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RAIDD is an Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway[1][2][3][4][5][6].

  • Subcellular Localization

    Cytoplasm; Nucleus

  • Expression


    Tissue_specificity:Constitutively expressed in most tissues, with particularly high expression in human heart, testis, liver, skeletal muscle, fetal liver and kidney

  • Isoforms & Post-Translational Modification

    P78560 has 2 isomers: P78560-1: 22745 Da (predicted); P78560-2: 11826 Da (predicted).

  • Subunit

    Forms a complex named the PIDDosome with PIDD1 and CASP2 (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:8985253, PubMed:9044836).

  • SwissProt ID

    P78560

  • Gene ID
    8738 [NCBI]
  • Synonyms

    CRADD; MGC9163; RAIDD; Death adaptor molecule RAIDD; Death domain containing protein CRADD

  • Research Field

    Cell Biology

[1]. Tinel A, et al. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004 May 7;304(5672):843-6. [Content Brief]

[2]. Vakifahmetoglu H, et al. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene. 2006 Sep 14;25(41):5683-92. [Content Brief]

[3]. Tinel A, et al. Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 2007 Jan 10;26(1):197-208. [Content Brief]

[4]. Park HH, et al. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 2007 Feb 9;128(3):533-46. [Content Brief]

[5]. Ahmad M, et al. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res. 1997 Feb 15;57(4):615-9. [Content Brief]

[6]. Duan H, et al. RAIDD is a new 'death' adaptor molecule. Nature. 1997 Jan 2;385(6611):86-9. [Content Brief]

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RAIDD Antibody (YA1815) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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