RASGRP1 Antibody (YA2546)(PBS only)
(Synonyms: V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII)RASGRP1 Antibody (YA2546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RASGRP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
RASGRP1 Antibody (YA2546) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RASGRP1.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 90 kDa
A synthetic peptide of human Rasgrp1
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RASGRP1 functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types[1][2][3][4][5][6][7][8].
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Subcellular Localization
Cytoplasm, cytosol; Cell membrane; Peripheral membrane protein; Golgi apparatus membrane; Peripheral membrane protein; Endoplasmic reticulum membrane; Peripheral membrane protein
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Expression
Tissue_specificity:Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level) . Expressed in NK cells (at protein level) (PubMed:19933860) -
Isoforms & Post-Translational Modification
O95267 has 5 isomers: O95267-1: 90402 Da (predicted); O95267-2: 86625 Da (predicted); O95267-3: 68170 Da (predicted); O95267-4: 55100 Da (predicted); O95267-5: 62674 Da (predicted).
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Subunit
Homodimer (PubMed:23908768). Forms a signaling complex with DGKZ and HRAS (PubMed:11257115). Interacts with F-actin (PubMed:12839994). Interacts with SKAP1 (PubMed:17658605)
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SwissProt ID
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Synonyms
V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII
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Research Field
Neuroscience
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