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RGS10 Antibody (YA8172)(PBS only)

(Synonyms: Regulator of G-protein signaling 10, RGS10)

RGS10 Antibody (YA8172) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RGS10.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • RGS10 Antibody (YA8172)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:2000-2500

Product Details

Description

RGS10 Antibody (YA8172) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to RGS10.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 21 kDa
Immunogen

Full length human recombinant protein of human RGS10 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    RGS10 regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein[1][2][3][4][5].

  • Subcellular Localization

    Cytoplasm, cytosol,Nucleus,Nucleus

  • Isoforms & Post-Translational Modification

    O43665 has three isomers: O43665-3: 21210 Da (predicted); O43665-1: 20236 Da (predicted); O43665-2: 19608 Da (predicted).

  • Subunit

    Interacts with GNAZ, GNAI1 and GNAI3 (PubMed:11443111, PubMed:18434541, PubMed:8774883)

  • SwissProt ID

    O43665

  • Synonyms

    Regulator of G-protein signaling 10, RGS10

RGS10 Antibody (YA8172)(PBS only) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • RGS10 Antibody (YA8172)(PBS only) Product Image