RGS17 Antibody (YA7938)
(Synonyms: hRGS17; RGS-17; RGSZ2)RGS17 Antibody (YA7938) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RGS17.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
RGS17 Antibody (YA7938) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RGS17.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 24.2 kDa
Full length human recombiant protein of human RGS17 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RGS17 regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins[1].
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Subcellular Localization
Membrane,Synapse, synaptosome,Nucleus,Cytoplasm
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Expression
Tissue_Specificity: Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes -
Isoforms & Post-Translational Modification
Q9UGC6: 210 amino acids, molecular weight 24359 Da.
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Subunit
Interacts with GNAI1 and GNAQ (PubMed:18434541)
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SwissProt ID
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Synonyms
hRGS17; RGS-17; RGSZ2
Documentation
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