RLIM Antibody (YA8831)(PBS only)

Cat. No.: HY-P89147A: Data Sheet User Guide for Antibodies
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RLIM Antibody (YA8831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RLIM.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RLIM Antibody (YA8831) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RLIM.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NVW2

Immunogen

Full length human recombinant protein of human RLIM produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Expressed in many tissues

Isoforms & Post-Translational Modification：Q9NVW2 has two isomers: Q9NVW2-1: 68549 Da (predicted); Q9NVW2-2: 52638 Da (predicted).

Subunit：Interacts with LIM/homeobox factors such as LHX3

Synonyms

NY-REN-43; RNF12

Documentation

User Guide for Antibodies (1077 KB)