RRAS2 Antibody (YA10061)
(Synonyms: TC21, RRAS2, Ras-related protein R-Ras2, Ras-like protein TC21, Teratocarcinoma oncogene)RRAS2 Antibody (YA10061) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to RRAS2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
RRAS2 Antibody (YA10061) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to RRAS2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
Purified recombinant protein of human RRAS2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RRAS2 is a GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes. Regulates craniofacial development[1][2][3].
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Subcellular Localization
Cell membrane; Golgi apparatus membrane
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Expression
Tissue_Specificity: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. -
Isoforms & Post-Translational Modification
RRAS2 has 4 isoforms, P62070-1: amino acid length is 204, molecular weight is 23400 Da (predicted); P62070-2: amino acid length is 127, molecular weight is 15094 Da (predicted); P62070-3: amino acid length is 169, molecular weight is 19841 Da (predicted); P62070-4: amino acid length is 210, molecular weight is 24196 Da (predicted).May be post-translationally modified by both palmitoylation and polyisoprenylation
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Subunit
Interacts with RASSF5
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SwissProt ID
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Synonyms
TC21, RRAS2, Ras-related protein R-Ras2, Ras-like protein TC21, Teratocarcinoma oncogene
Documentation
References
[1]. Capri Y, et al. Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome. Am J Hum Genet. 2019 Jun 6;104(6):1223-1232. [Content Brief]
[2]. Niihori T, et al. Germline-Activating RRAS2 Mutations Cause Noonan Syndrome. Am J Hum Genet. 2019 Jun 6;104(6):1233-1240. [Content Brief]
[3]. Bernal Astrain G, et al. The small GTPase MRAS is a broken switch. Nat Commun. 2025 Jan 14;16(1):647. [Content Brief]
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