SERBP1 Antibody (YA8686)(PBS only)

Cat. No.: HY-P89002A: Data Sheet User Guide for Antibodies
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SERBP1 Antibody (YA8686) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERBP1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SERBP1 Antibody (YA8686) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERBP1.

Host

Mouse

Molecular Weight

Predicted band size: 44.1 kDa

Species Reactivity

Human, Dog, Rat, Monkey, Mouse

SwissProt ID

Q8NC51

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-262 of human SERBP1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-5000

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742)

Subcellular Localization：Cytoplasm,Nucleus,Cytoplasm, perinuclear region

Expression：
Tissue_Specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain

Isoforms & Post-Translational Modification：Q8NC51 has four isomers: Q8NC51-1: 44965 Da (predicted); Q8NC51-2: 44257 Da (predicted); Q8NC51-3: 43135 Da (predicted); Q8NC51-4: 42427 Da (predicted).
Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation

Subunit：Associates with mature 80S ribosomes (PubMed:23636399, PubMed:32687489, PubMed:36691768)

Synonyms

CGI-55; CHD3IP; HABP4L; PAI-RBP1; PAIRBP1

Documentation

User Guide for Antibodies (1077 KB)