SERBP1 Antibody (YA8686)
(Synonyms: CGI-55; CHD3IP; HABP4L; PAI-RBP1; PAIRBP1)SERBP1 Antibody (YA8686) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERBP1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-5000 |
Product Details
SERBP1 Antibody (YA8686) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERBP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 44.1 kDa
Human recombinant protein fragment corresponding to amino acids 1-262 of human SERBP1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SERBP1 is a Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation[1][2][3].
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Subcellular Localization
Cytoplasm,Nucleus,Cytoplasm, perinuclear region
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Expression
Tissue_Specificity: Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain -
Isoforms & Post-Translational Modification
Q8NC51 has four isomers: Q8NC51-1: 44965 Da (predicted); Q8NC51-2: 44257 Da (predicted); Q8NC51-3: 43135 Da (predicted); Q8NC51-4: 42427 Da (predicted).
Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation -
Subunit
Associates with mature 80S ribosomes (PubMed:23636399, PubMed:32687489, PubMed:36691768)
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SwissProt ID
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Synonyms
CGI-55; CHD3IP; HABP4L; PAI-RBP1; PAIRBP1
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