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SFTPA1 + SFTPA2 Antibody (YA1318)

(Synonyms: Collectin-4, COLEC4, Collectin-5, COLEC5, PSAP, SFTP1, SFTPA, SFTPA1B, SFTPA2B)
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SFTPA1 + SFTPA2 Antibody (YA1318) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SFTPA1 + SFTPA2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, Glycerol and BSA

  • Conjugation:
    Non-conjugated
  • SFTPA1 + SFTPA2 Antibody (YA1318) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:1000-1:3000

Product Details

Description

SFTPA1 + SFTPA2 Antibody (YA1318) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SFTPA1 + SFTPA2.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size:27 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 27 kDa
Species Reactivity Database
Immunogen

Peptide

Sensitivity

Endogenous

Purification

Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3103685

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, Glycerol and BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    SFTPA1 + SFTPA2 is a Q8IWL2: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages; (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen
    Q8IWL1: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration
    [1][2][3][4][5].

  • Subcellular Localization

    Q8IWL2: Secreted; Secreted, extracellular space, extracellular matrix; Secreted, extracellular space, surface film
    Q8IWL1: Secreted; Secreted, extracellular space, extracellular matrix; Secreted, extracellular space, surface film

  • Isoforms & Post-Translational Modification

    Q8IWL2 has 2 isomers: Q8IWL2-1: 26242 Da (predicted); Q8IWL2-2: 27736 Da (predicted).
    N-acetylated

  • Subunit

    Q8IWL2: Oligomeric complex of 6 set of homotrimers (PubMed:2610270). Interacts with CD93 (PubMed:7977768)
    Q8IWL1: Oligomeric complex of 6 set of homotrimers

  • SwissProt ID

    Q8IWL2 / Q8IWL1

  • Gene ID
    653509 [NCBI] / 729238 [NCBI]
  • Synonyms

    Collectin-4, COLEC4, Collectin-5, COLEC5, PSAP, SFTP1, SFTPA, SFTPA1B, SFTPA2B

  • Research Field

    Signal transduction

SFTPA1 + SFTPA2 Antibody (YA1318) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • SFTPA1 + SFTPA2 Antibody (YA1318) Product Image
    1/16
  • SFTPA1 + SFTPA2 Antibody (YA1318) Product Image