SFTPA1 + SFTPA2 Antibody (YA1318)

Cat. No.: HY-P81573: Data Sheet COA
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SFTPA1 + SFTPA2 Antibody (YA1318) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SFTPA1 + SFTPA2.

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사이즈	재고	수량
10 μL	해외재고보유	Estimated Time of Arrival: December 31
50 μL	해외재고보유	Estimated Time of Arrival: December 31
100 μL	해외재고보유	Estimated Time of Arrival: December 31
250 μL	견적 받기

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SFTPA1 + SFTPA2 Antibody (YA1318) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

SFTPA1 + SFTPA2 Antibody (YA1318) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SFTPA1 + SFTPA2.

Host

Rabbit

Clonality

Recombinant, Monoclonal

분자량

Predicted band size: 27 kDa;

Observed band size:27 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q8IWL2 / Q8IWL1

Gene ID

653509 [NCBI] / 729238 [NCBI]

Immunogen

Peptide

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:3000

Sensitivity	Endogenous	Purity	Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, Glycerol and BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Q8IWL2: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity) ; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule (PubMed:17158455, PubMed:21203928). Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages (PubMed:21123169) ; (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen (PubMed:15845487, PubMed:25139904). When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen (PubMed:25139904)
Q8IWL1: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration

Subcellular Localization：Q8IWL2: Secreted; Secreted, extracellular space, extracellular matrix; Secreted, extracellular space, surface film
Q8IWL1: Secreted; Secreted, extracellular space, extracellular matrix; Secreted, extracellular space, surface film

Isoforms & Post-Translational Modification：Q8IWL2 has 2 isomers: Q8IWL2-1: 26242 Da (predicted); Q8IWL2-2: 27736 Da (predicted).
N-acetylated

Subunit：Q8IWL2: Oligomeric complex of 6 set of homotrimers (PubMed:2610270). Interacts with CD93 (PubMed:7977768)
Q8IWL1: Oligomeric complex of 6 set of homotrimers

RRID

AB_3103685

Database

Entrez Gene: 653509 Human ; 729238 Human

SwissProt: Q8IWL2 Human ; Q8IWL1 Human

OMIM: 178630 Human

Research Field

Signal transduction

Synonyms

Collectin-4, COLEC4, Collectin-5, COLEC5, PSAP, SFTP1, SFTPA, SFTPA1B, SFTPA2B

각종 서류

Select Batch:

Data Sheet (230 KB) SDS (252 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)

SFTPA1 + SFTPA2 Antibody (YA1318) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SFTPA1 + SFTPA2 Antibody (YA1318)

SFTPA1 + SFTPA2 Antibody (YA1318) Featured Recommendations:

Product Detail

Background

제품 설명

SFTPA1 + SFTPA2 Antibody (YA1318) Related Classifications

최근 본 상품:

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SAFETY DATA SHEET (SDS)

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