SLC25A12 Antibody (YA1985)(PBS only)

Cat. No.: HY-P82240A: Data Sheet User Guide for Antibodies
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SLC25A12 Antibody (YA1985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC25A12.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

SLC25A12 Antibody (YA1985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC25A12.

Host

Rabbit

Molecular Weight

Predicted band size: 75 kDa;

Observed band size: 75 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Mouse, Rat

SwissProt ID

O75746

Gene ID

8604 [NCBI]

Immunogen

A synthetic peptide of human SLC25A12

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575, PubMed:38945283). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton (PubMed:11566871). Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA) (PubMed:38945283)

Subcellular Localization：Mitochondrion inner membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney

Isoforms & Post-Translational Modification：O75746 has 2 isomers: O75746-1: 74762 Da (predicted); O75746-2: 62720 Da (predicted).

Subunit：Homodimer (via N-terminus)

Research Field

Neuroscience

Synonyms

AGC1; ARALAR; EIEE39

Documentation

User Guide for Antibodies (1077 KB)