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SLC25A12 Antibody (YA1985)(PBS only)

(Synonyms: AGC1; ARALAR; EIEE39)

SLC25A12 Antibody (YA1985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC25A12.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IP

  • Reactivity :

    Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • SLC25A12 Antibody (YA1985)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:500-1:1000 1:20

Product Details

Description

SLC25A12 Antibody (YA1985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC25A12.

  • Host Rabbit
  • Species Reactivity
    Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 75 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 75 kDa
Immunogen

A synthetic peptide of human SLC25A12

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    SLC25A12 is a Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA)[1][2][3][4].

  • Subcellular Localization

    Mitochondrion inner membrane; Multi-pass membrane protein

  • Expression


    Tissue_specificity:Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney

  • Isoforms & Post-Translational Modification

    O75746 has 2 isomers: O75746-1: 74762 Da (predicted); O75746-2: 62720 Da (predicted).

  • Subunit

    Homodimer (via N-terminus)

  • SwissProt ID

    O75746

  • Gene ID
    8604 [NCBI]
  • Synonyms

    AGC1; ARALAR; EIEE39

  • Research Field

    Neuroscience

SLC25A12 Antibody (YA1985)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • SLC25A12 Antibody (YA1985)(PBS only) Product Image