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SLC39A5 Antibody (YA8179)(PBS only)

(Synonyms: LZT-Hs7; MYP24; ZIP5)

SLC39A5 Antibody (YA8179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC39A5.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • SLC39A5 Antibody (YA8179)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-800

Product Details

Description

SLC39A5 Antibody (YA8179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC39A5.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 56.1 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 48-178 of human SLC39A5 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    SLC39A5 is an Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable. In addition, is also a high affinity copper transporter in vitro. Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development[1][2].

  • Subcellular Localization

    Basolateral cell membrane

  • Expression


    Tissue_Specificity: Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney

  • Isoforms & Post-Translational Modification

    Q6ZMH5: 540 amino acids, molecular weight 56461 Da.

  • Subunit

    Homodimer

  • SwissProt ID

    Q6ZMH5

  • Synonyms

    LZT-Hs7; MYP24; ZIP5

SLC39A5 Antibody (YA8179)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • SLC39A5 Antibody (YA8179)(PBS only) Product Image