2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. SOX2 Antibody (YA066)

SOX2 Antibody (YA066) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOX2.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE SOX2 Antibody (YA066)

WB

    SOX2 Antibody (YA066) purchased from MCE. Usage Cited in: Endocrine. 2024 Jun;84(3):1051-1063.  [Abstract]

    WB detectd the expression of PI3K/Akt pathway and downstream target molecules in K1 and CAL-62 transfected with sh-ID2, Ctrl, or oe-ID2. After MK-2206 (AKT inhibitor) treatment.
    • WB: Western Blot;
    • IHC-P: Immunohistochemistry-Paraffin;
    • IHC-F: Immunohistochemistry-Frozen;
    • ICC/IF: Immunocytochemistry/Immunofluorescence;
    • IF-Tissue: Immunofluorescence-Tissue;
    • mIHC: Multiplex Immunohistochemical;
    • IP: Immunoprecipitation;
    • ChIP: Chromatin Immunoprecipitation;
    • FC: Flow Cytometry;
    • ELISA: Enzyme Linked Immunosorbent Assay

    • Product Detail

    • Background

    • Documentation

    • References

    Description

    SOX2 Antibody (YA066) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOX2.
    Host

    Rabbit
    Clonality

    Recombinant, Monoclonal
    Molecular Weight
    Predicted band size: 34 kDa;
    Observed band size: 34 kDa
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
    Species Reactivity
    Human
    SwissProt ID
    Gene ID
    Immunogen

    Synthetic peptide corresponding to Human SOX2.AA range:1-100.
    Application &
    Dilution Ratio
    Application Dilution Ratio
    IHC-P
    IHC-P: Immunohistochemistry-Paraffin
    		1:1000
    Sensitivity Endogenous Purity Protein A affinity purified.
    Conjugation Non-conjugated Modification Unmodified
    Isotype IgG  
    Appearance

    Liquid
    Formulation

    Supplied in 1*PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
    Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
    Shipping

    Shipping with blue ice.
    Background
    Function：Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity)
    Subcellular Localization：Nucleus speckle; Cytoplasm; Nucleus
    Subunit：Interacts with ZSCAN10 (By similarity). Interacts with SOX3 and FGFR1 (By similarity). Interacts with GLIS1 (PubMed:21654807). Interacts with POU5F1; binds synergistically with POU5F1 to DNA (By similarity). Interacts with DDX56 (By similarity). Interacts with L3MBTL3 and DCAF5; the interaction requires methylation at Lys-42 and is necessary to target SOX2 for ubiquitination by the CRL4-DCAF5 E3 ubiquitin ligase complex (PubMed:30442713). Interacts with RCOR1/CoREST (By similarity) (PubMed:30442713). Interacts with PHF20L1; the interaction requires methylation at Lys-42 and Lys-117 and protects SOX2 from degradation (PubMed:29358331). Interacts with TRIM26; this interaction prevents ubiquitination by WWP2 (PubMed:34732716)
    RRID
    Database

    Entrez Gene: 6657 Human

    SwissProt: P48431 Human

    OMIM: 206900 Human

    Research Field

    Neuroscience
    Documentation
    SDS (251 KB)

    COA (205 KB)

    User Guide for Antibodies (1077 KB)
    References

    SOX2 Antibody (YA066) Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    HY-P80334
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