SUPT16H Antibody (YA7888)(PBS only)
(Synonyms: CDC68; FACTP140; SPT16; SPT16/CDC68)SUPT16H Antibody (YA7888) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SUPT16H.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
SUPT16H Antibody (YA7888) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SUPT16H.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 187-282 of human SUPT16H produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SUPT16H component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)
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Subcellular Localization
Nucleus,Chromosome
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Expression
Tissue_Specificity: Ubiquitous -
Isoforms & Post-Translational Modification
Q9Y5B9: 1047 amino acids, molecular weight 119914 Da.
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Subunit
Interacts with MYOG (via C-terminal region) (By similarity)
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SwissProt ID
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Synonyms
CDC68; FACTP140; SPT16; SPT16/CDC68
Documentation
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