Syndapin-2 Antibody (YA10082)
(Synonyms: Protein kinase C and casein kinase substrate in neurons protein 2, Syndapin-2, Syndapin-II, SdpII, PACSIN2)Syndapin-2 Antibody (YA10082) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Syndapin-2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
Syndapin-2 Antibody (YA10082) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Syndapin-2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 56 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 55 kDa
Purified recombinant protein of human Syndapin-2.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Syndapin-2 regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity)[1][2][3][4].
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasmic vesicle membrane; Cell projection, ruffle membrane; Early endosome; Recycling endosome membrane; Cell membrane; Cell projection; Membrane, caveola; Cell junction, adherens junction
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Expression
Tissue_Specificity: Widely expressed. -
Isoforms & Post-Translational Modification
Syndapin-2 has 2 isoforms, Q9UNF0-1: amino acid length is 486, molecular weight is 55739 Da (predicted); Q9UNF0-2: amino acid length is 445, molecular weight is 51353 Da (predicted).
Phosphorylated by casein kinase 2 (CK2). -
Subunit
Homodimer (By similarity).
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SwissProt ID
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Synonyms
Protein kinase C and casein kinase substrate in neurons protein 2, Syndapin-2, Syndapin-II, SdpII, PACSIN2
Documentation
References
[1]. de Kreuk BJ, et al. The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. J Cell Sci. 2011 Jul 15;124(Pt 14):2375-88. [Content Brief]
[2]. de Kreuk BJ, et al. The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J Biol Chem. 2012 Dec 21;287(52):43438-53. [Content Brief]
[3]. Goh SL, et al. Versatile membrane deformation potential of activated pacsin. PLoS One. 2012;7(12):e51628. [Content Brief]
[4]. Giridharan SS, et al. Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis. Mol Biol Cell. 2013 Jun;24(11):1776-90, S1-15. [Content Brief]
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