SYNM Antibody (YA8182)
(Synonyms: DMN; SYN)SYNM Antibody (YA8182) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYNM.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
SYNM Antibody (YA8182) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SYNM.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 172.7 kDa
Human recombinant protein fragment corresponding to amino acids 329-580 of human SYNM produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SYNM is a Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells
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Subcellular Localization
Cytoplasm, cytoskeleton,Cell junction, adherens junction
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Expression
Tissue_Specificity: Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms -
Isoforms & Post-Translational Modification
O15061 has three isomers: O15061-1: 172868 Da (predicted); O15061-2: 140163 Da (predicted); O15061-3: 39070 Da (predicted).
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Subunit
Interacts with GFAP and VIM (By similarity)
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SwissProt ID
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Synonyms
DMN; SYN
Documentation
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