TARC/CCL17 Antibody (YA1211)(PBS only)

Cat. No.: HY-P81466A: Data Sheet User Guide for Antibodies
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TARC/CCL17 Antibody (YA1211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TARC/CCL17.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

TARC/CCL17 Antibody (YA1211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TARC/CCL17.

Host

Rabbit

Molecular Weight

Predicted band size: 11 kDa;

Observed band size: 11 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q92583

Gene ID

6361 [NCBI]

Immunogen

Recombinant protein of human TARC

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:8702936, PubMed:9169480). Acts by binding to CCR4 at T-cell surface (PubMed:10540332, PubMed:9169480). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (By similarity). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity)

Subcellular Localization：Secreted

Expression：
Tissue_specificity:Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine (PubMed:8702936) . Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells (PubMed:8702936)

Induction:In monocytes, up-regulated by IL4 and by GM-CSF/CSF2 in an IRF4-dependent manner (at protein level)

Research Field

Immunology

Synonyms

TARC; CCL17; SCYA17; C-C motif chemokine 17; C-C motif chemokine 17; Small-inducible cytokine A17; Thymus and activation-regulated chemokine

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/gh3-cell.html