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TBX1 Antibody (YA7754)(PBS only)

(Synonyms: CAFS; CATCH22; CTHM; DGCR; DGS; DORV; TBX1C; TGA; VCF; VCFS)

TBX1 Antibody (YA7754) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TBX1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TBX1 Antibody (YA7754)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:4000 1:150-500

Product Details

Description

TBX1 Antibody (YA7754) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TBX1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 43 kDa
Immunogen

Full length human recombinant protein of human TBX1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TBX1 transcription factor that plays a key role in cardiovascular development by promoting pharyngeal arch segmentation during embryonic development. Also involved in craniofacial muscle development. Together with NKX2-5, acts as a regulator of asymmetric cardiac morphogenesis by promoting expression of PITX2. Acts upstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch. Required for hair follicle stem cell self-renewal. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence[1][2].

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    O43435 has three isomers: O43435-1: 43133 Da (predicted); O43435-2: 40353 Da (predicted); O43435-3: 52666 Da (predicted).

  • Subunit

    Binds DNA as a dimer (PubMed:11111039, PubMed:22095455)

  • SwissProt ID

    O43435

  • Synonyms

    CAFS; CATCH22; CTHM; DGCR; DGS; DORV; TBX1C; TGA; VCF; VCFS

TBX1 Antibody (YA7754)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TBX1 Antibody (YA7754)(PBS only) Product Image