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TIPIN Antibody (YA8113)(PBS only)

(Synonyms: FLJ20516)

TIPIN Antibody (YA8113) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TIPIN.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TIPIN Antibody (YA8113)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

TIPIN Antibody (YA8113) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TIPIN.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 34.3 kDa
Immunogen

Full length human recombinant protein of human TIPIN produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TIPIN plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress[1][2][3][4][5].

  • Subcellular Localization

    Cytoplasm,Nucleus

  • Isoforms & Post-Translational Modification

    Q9BVW5: 301 amino acids, molecular weight 34555 Da.

  • Subunit

    Interacts with TIMELESS (via N-terminus), which impairs TIMELESS self-association (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:28334766, PubMed:34694004, PubMed:34700328)

  • SwissProt ID

    Q9BVW5

  • Synonyms

    FLJ20516

TIPIN Antibody (YA8113)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • TIPIN Antibody (YA8113)(PBS only) Product Image
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  • TIPIN Antibody (YA8113)(PBS only) Product Image