Transmembrane Protein 192 Antibody (YA2215)
(Synonyms: Transmembrane protein 192)Transmembrane Protein 192 Antibody (YA2215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Transmembrane Protein 192 Antibody (YA2215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Transmembrane Protein 192.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 31 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 31 kDa
Recombinant protein of human TMEM192
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Transmembrane protein 192 (TMEM192) is a lysosomal/late endosomal membrane protein containing four transmembrane segments. It exists as a homodimer, with an N-terminal dileucine motif mediating lysosomal targeting and a C-terminal cysteine motif mediating disulfide bond formation. It is widely expressed throughout the body, but is significantly overexpressed in tumor cells. Functionally, TMEM192 is involved in maintaining lysosomal membrane integrity and acidification, regulating autophagy-apoptosis crosstalk (liver cancer cells), mediating retinoic acid-induced autophagy along the TIG1-TMEM192 axis (cervical cancer), and is a key molecule in lysosomal autophagy. TMEM192 plays an important role under stress conditions such as tumor and lysosomal damage.
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Subcellular Localization
Lysosome membrane; Multi-pass membrane protein; Late endosome
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Expression
Tissue_specificity:It is highly expressed in the kidneys, liver, lungs, and pancreas. -
Isoforms & Post-Translational Modification
Q8IY95 has 2 isomers: Q8IY95-1: 30922 Da (predicted); Q8IY95-2: 30549 Da (predicted).
Not N-glycosylated -
Subunit
Homodimer
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SwissProt ID
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Synonyms
Transmembrane protein 192
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Research Field
Tags & Cell Markers
Documentation
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