ZFAND5 Antibody (YA8188)

Cat. No.: HY-P88504: Ficha de datos User Guide for Antibodies
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ZFAND5 Antibody (YA8188) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND5.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

ZFAND5 Antibody (YA8188) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFAND5.

Host

Mouse

Clonality

Monoclonal

Peso molecular

Predicted band size: 23 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O76080

Immunogen

Full length human recombinant protein of human ZFAND5 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Pureza	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level)

Isoforms & Post-Translational Modification：O76080: 213 amino acids, molecular weight 23132 Da.

Subunit：Interacts with ubiquitin and polyubiquitinated proteins

Synonyms

ZA20D2; ZFAND5A; ZNF216

Documentación

User Guide for Antibodies (1077 KB)