ZFP57 Antibody (YA8829)(PBS only)

Cat. No.: HY-P89145A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

ZFP57 Antibody (YA8829) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP57.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ZFP57 Antibody (YA8829) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP57.

Host

Mouse

Species Reactivity

Human, Mouse

SwissProt ID

Q9NU63

Immunogen

Full length human recombinant protein of human ZFP57 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:2000-2500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs) (PubMed:18622393, PubMed:30602440). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance (PubMed:30602440). Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q9NU63 has three isomers: Q9NU63-1: 51919 Da (predicted); Q9NU63-2: 59176 Da (predicted); Q9NU63-3: 61358 Da (predicted).

Synonyms

bA145L22; bA145L22.2; C6orf40; TNDM1; ZNF698

Documentation

User Guide for Antibodies (1077 KB)