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ZFP57 Antibody (YA8829)(PBS only)

(Synonyms: bA145L22; bA145L22.2; C6orf40; TNDM1; ZNF698)

ZFP57 Antibody (YA8829) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP57.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • ZFP57 Antibody (YA8829)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:2000-2500

Product Details

Description

ZFP57 Antibody (YA8829) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFP57.

  • Host Mouse
  • Species Reactivity
    Human, Mouse
Immunogen

Full length human recombinant protein of human ZFP57 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    ZFP57 transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element[1][2].

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    Q9NU63 has three isomers: Q9NU63-1: 51919 Da (predicted); Q9NU63-2: 59176 Da (predicted); Q9NU63-3: 61358 Da (predicted).

  • SwissProt ID

    Q9NU63

  • Synonyms

    bA145L22; bA145L22.2; C6orf40; TNDM1; ZNF698

ZFP57 Antibody (YA8829)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • ZFP57 Antibody (YA8829)(PBS only) Product Image