1807503-82-7
Chemical Structure
Coumarin 343 azide
- CAS. Nr.: 1807503-82-7
- Formula:C22H27N5O5
- Molecular Weight:441.48
InChIKey: ZQXMHGIAYIMCGF-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCOCCOCCNC(C1=CC2=C(OC1=O)C(CCCN3CCC4)=C3C4=C2)=O
Biological Activity: Coumarin 343 azide is a fluorescent dye used for the fluorescent labeling of alkyne-containing biomolecules based on click chemistry. Its detection mechanism relies on the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), a type of click reaction: under mild aqueous conditions, the azide group of this dye selectively reacts with the alkyne moiety of propargyl geldanamycin to form a triazole bond that conjugates the fluorescent dye to the target biomolecule; fluorescence is generated upon successful conjugation to the target[1].
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Coumarin 343 azide | Coumarin 343 azide is a fluorescent dye used for the fluorescent labeling of alkyne-containing biomolecules based on click chemistry. Its detection mechanism relies on the copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC), a type of click reaction: under mild aqueous conditions, the azide group of this dye selectively reacts with the alkyne moiety of propargyl geldanamycin to form a triazole bond that conjugates the fluorescent dye to the target biomolecule; fluorescence is generated upon successful conjugation to the target. | |||||||||||||||||||||
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