3053583-60-8
3053583-60-8
Chemical Structure
STAT3/CAIX-IN-1
- CAS. Nr.: 3053583-60-8
- Formula:C28H23F6N5O5S2
- Molecular Weight:687.63
InChIKey: IRZMHVSJJQXUKJ-KLCVKJMQSA-N
SMILES: O=C(NC1=NN=C(S(=O)(N)=O)S1)CCCC(N2C/C(C(/C(C2)=C/C3=CC=C(C(F)(F)F)C=C3)=O)=C\C4=CC=C(C(F)(F)F)C=C4)=O
Biological Activity: STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM). STAT3/CAIX-IN-1 induces ferroptosis by increases the levels of reactive oxygen species (ROS) and lipid peroxides. STAT3/CAIX-IN-1 inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 can be used for the study of triple-negative breast cancer (TNBC)[1].
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STAT3/CAIX-IN-1 | STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM). STAT3/CAIX-IN-1 induces ferroptosis by increases the levels of reactive oxygen species (ROS) and lipid peroxides. STAT3/CAIX-IN-1 inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 can be used for the study of triple-negative breast cancer (TNBC). | |||||||||||||||||||||
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