CDK7-IN-26
CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor (IC50: 7.4 nM). CDK7-IN-26 potently inhibits the growth of triple-negative breast cancer (TNBC) cell line-derived xenograft (CDX) tumors in vivo and inhibits MDA-MB-453 cells in vitro with an IC50 of 0.15 μM.
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- CAS. Nr.: 3024545-79-4
- Formel: C22H22FN6OPS
- Molecular Weight:468.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
IC50: 7.4 nM (CDK7)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | EC50 |
0.32 μM
Compound: 36
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Antiproliferative activity against human MDA-MB-231 cells incubated for 120 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 120 hrs by CCK-8 assay
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[PMID: 38000213] |
| MDA-MB-453 | EC50 |
0.15 μM
Compound: 36
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Antiproliferative activity against human MDA-MB-453 cells incubated for 120 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-453 cells incubated for 120 hrs by CCK-8 assay
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[PMID: 38000213] |
Chemical Information
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CAS. Nr. 3024545-79-4
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Molecular Weight 468.49
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Formel C22H22FN6OPS
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SMILES
O=P(C)(C1=C(C=CC2=C1NC=C2C3=NC(N[C@H]4C[C@H](F)CNC4)=NC5=C3SC=C5)C#N)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CDK7-IN-26 Related Classifications
HY-157210 Related Classifications
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