2. MAPK/ERK Pathway
  3. Raf
  4. B-Raf IN 5

B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.

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B-Raf IN 5

B-Raf IN 5 화학구조

CAS No. : 2648698-30-8

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B-Raf IN 5 Related Antibodies

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제품 설명

B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
2.06 nM
Compound: 3b
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
[PMID: 34958586]
분자량

583.01

화학식

C23H18ClF3N6O3S2
CAS No.
SMILES

O=S(C1=CC(F)=CC=C1F)(NC2=CC(Cl)=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCOC5)=N3)=C2F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Keywords:

B-Raf IN 52648698-30-8RafRaf kinasesB-RafPXRcancerInhibitorinhibitorinhibit

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상품명:
B-Raf IN 5
Cat. No.:
HY-142820
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