Bis(pinacolato)diborane
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Bis(pinacolato)diborane is an organoboron reagent. Bis(pinacolato)diborane serves as a source of the [Bpin] moiety with pronounced nucleophilic character and is used in the synthesis of various organoboranes, including organoboron compounds and arylboronates.Bis(pinacolato)diborane reacts with p-benzyne to produce tetraborylated products through a series of steps involving addition and 1,2-migration of the boryl group.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 73183-34-3
- Formula: C12H24B2O4
- Molecular Weight:253.94
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Bis(pinacolato)diborane (0.8 mmol-4.0 mmol; 16 h) can tetraborate p-benzoyne generated from 1,2-diethynylbenzene derivatives[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 73183-34-3
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Appearance Solid
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Molecular Weight 253.94
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Formula C12H24B2O4
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Color White to off-white
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SMILES
CC1(C)C(C)(C)OB(B2OC(C)(C)C(C)(C)O2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (196.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Pécharman AF, et al. Easy access to nucleophilic boron through diborane to magnesium boryl metathesis. Nat Commun. 2017;8:15022. Published 2017 Apr 7. [Content Brief]
[2]. Nakatsuka S, et al. Tetraborylation of p-Benzynes Generated by the Masamune-Bergman Cyclization through Reaction Design Based on the Reaction Path Network. JACS Au. 2024;4(7):2578-2584. Published 2024 Jun 20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.9379 mL | 19.6897 mL | 39.3794 mL | 98.4485 mL |
| 5 mM | 0.7876 mL | 3.9379 mL | 7.8759 mL | 19.6897 mL | |
| 10 mM | 0.3938 mL | 1.9690 mL | 3.9379 mL | 9.8448 mL | |
| 15 mM | 0.2625 mL | 1.3126 mL | 2.6253 mL | 6.5632 mL | |
| 20 mM | 0.1969 mL | 0.9845 mL | 1.9690 mL | 4.9224 mL | |
| 25 mM | 0.1575 mL | 0.7876 mL | 1.5752 mL | 3.9379 mL | |
| 30 mM | 0.1313 mL | 0.6563 mL | 1.3126 mL | 3.2816 mL | |
| 40 mM | 0.0984 mL | 0.4922 mL | 0.9845 mL | 2.4612 mL | |
| 50 mM | 0.0788 mL | 0.3938 mL | 0.7876 mL | 1.9690 mL | |
| 60 mM | 0.0656 mL | 0.3282 mL | 0.6563 mL | 1.6408 mL | |
| 80 mM | 0.0492 mL | 0.2461 mL | 0.4922 mL | 1.2306 mL | |
| 100 mM | 0.0394 mL | 0.1969 mL | 0.3938 mL | 0.9845 mL |
Bis(pinacolato)diborane Related Classifications
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