BMS-599626 dihydrochloride
Based on 3 publication(s) in Google Scholar
BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models.
For research use only. We do not sell to patients.
- CAS No.: 1781932-33-9
- Formula: C27H29Cl2FN8O3
- Molecular Weight:603.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) BMS-599626 dihydrochloride
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Biological Activity
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HER1 20 nM (IC50) |
HER2 30 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1781932-33-9
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Molecular Weight 603.48
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Formula C27H29Cl2FN8O3
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SMILES
FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C(NC(OC[C@@H]6COCCN6)=O)=C5)C)=C3)=CC=C1.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
Life Sci
Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARα and the inhibition of JunB expression. [Abstract]2021 Dec 16;289:120231. PMID: 34921867 -
BMC Pulm Med
The combination therapy of isomucronulatol 7-O-beta-glucoside (IMG) and CEP-9722 targeting ferroptosis-related biomarkers in non-small cell lung cancer (NSCLC). [Abstract]2023 May 11;23(1):162. PMID: 37165402
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-599626 dihydrochloride Related Classifications
HY-110333 Related Classifications
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