1781932-33-9
Chemical Structure
BMS-599626 dihydrochloride
- CAS No.: 1781932-33-9
- Formula:C27H29Cl2FN8O3
- Molecular Weight:603.48
IUPAC Name: (S)-morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate dihydrochloride
InChIKey: SKHKFWSXLCGMNF-IKXQUJFKSA-N
SMILES: FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C(NC(OC[C@@H]6COCCN6)=O)=C5)C)=C3)=CC=C1.Cl.Cl
Biological Activity: BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models[1].
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BMS-599626 dihydrochloride | BMS-599626 dihydrochloride is a small molecule pan-HER (human epidermal growth factor receptor) kinase inhibitor. BMS-599626 dihydrochloride primarily targets HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family. BMS-599626 inhibits the kinase activity of HER1 and HER2 by competing with their ATP-binding sites, and can inhibit the downstream signaling pathway by blocking the heterodimer formation of HER1 and HER2. BMS-599626 dihydrochloride can be used to study the antitumor effects of multiple HER1 or HER2 overexpressed tumor models. | |||||||||||||||||||||
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