2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG1-C2-Boc

Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Bromo-PEG1-C2-Boc

Bromo-PEG1-C2-Boc 화학구조

CAS No. : 1393330-36-3

사이즈 가격 재고 수량
250 mg 해외재고보유
1 g 해외재고보유
5 g 해외재고보유
10 g 해외재고보유
25 g 해외재고보유
50 g   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

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Bromo-PEG1-C2-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG1-C2-Boc Related Antibodies
분자량

253.13

화학식

C9H17BrO3
CAS No.
Appearance

Liquid (Density: 1.264±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCBr
선적

Room temperature in continental US; may vary elsewhere.
보관
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

H2O : ≥ 100 mg/mL (395.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9505 mL 19.7527 mL 39.5054 mL
5 mM 0.7901 mL 3.9505 mL 7.9011 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
순도&문서

Purity: 98.58%

SDS (393 KB)

COA (242 KB) HNMR (116 KB) GC (198 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.9505 mL 19.7527 mL 39.5054 mL 98.7635 mL
5 mM 0.7901 mL 3.9505 mL 7.9011 mL 19.7527 mL
10 mM 0.3951 mL 1.9753 mL 3.9505 mL 9.8763 mL
15 mM 0.2634 mL 1.3168 mL 2.6337 mL 6.5842 mL
20 mM 0.1975 mL 0.9876 mL 1.9753 mL 4.9382 mL
25 mM 0.1580 mL 0.7901 mL 1.5802 mL 3.9505 mL
30 mM 0.1317 mL 0.6584 mL 1.3168 mL 3.2921 mL
40 mM 0.0988 mL 0.4938 mL 0.9876 mL 2.4691 mL
50 mM 0.0790 mL 0.3951 mL 0.7901 mL 1.9753 mL
60 mM 0.0658 mL 0.3292 mL 0.6584 mL 1.6461 mL
80 mM 0.0494 mL 0.2469 mL 0.4938 mL 1.2345 mL
100 mM 0.0395 mL 0.1975 mL 0.3951 mL 0.9876 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bromo-PEG1-C2-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG1-C2-Boc1393330-36-3PROTAC LinkersInhibitorinhibitorinhibit

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Inquiry Information

상품명:
Bromo-PEG1-C2-Boc
Cat. No.:
HY-141364
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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