c-Met-IN-17 

c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC₅₀ of 0.031 μM. c-Met-IN-17 can be used in anticancer research.^[1]. c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

C-met-in-17 (compound 29) inhibits D1228V c-Met enzyme activity with an IC₅₀ of 0.068 μM by ADP-Glo assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

c-Met-IN-17 (0.5 mg/kg; i.v.; 0-24 h) shows excellent bioavailability in Wistar Rats^[1].
In vivo pharmacokinetic analysis in Wistar Rats^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

374.37

C₂₁H₁₅FN₄O₂

3034863-55-0

FC1=CC2=C(C(C3=CN(C(NC3=O)=O)C(C4=CC=CC=C4)C)=C1)NN=C2C#C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66(13):8782-8807.  [Content Brief]