c-Met-IN-18

Cat. No.: HY-149880: Ficha de datos Instrucciones de manejo
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c-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC₅₀ value of 0.013/0.20^e.c-Met-IN-18 can be used for the research of c-MET driven cancers. c-Met-IN-18 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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c-Met-IN-18 Estructura química

No. CAS : 3034863-56-1

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Descripciòn

c-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC₅₀ value of 0.013/0.20^e.c-Met-IN-18 can be used for the research of c-MET driven cancers^[1]. c-Met-IN-18 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

IC50: 0.013/0.20^e (WT/D1228V)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H1993	EC₅₀	0.339 μM Compound: 30	Inhibition of c-MET D1228V in human NCI-H1993 cells incubated for 4 hrs by HTRF assay Inhibition of c-MET D1228V in human NCI-H1993 cells incubated for 4 hrs by HTRF assay	[PMID: 37343272]

Peso molecular

374.37

Fòrmula

C₂₁H₁₅FN₄O₂

No. CAS

3034863-56-1

SMILES

O=C1NC(C(C2=CC(F)=CC3=C2NN=C3C#C)=CN1[C@H](C4=CC=CC=C4)C)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66(13):8782-8807. [Content Brief]

c-Met-IN-18 Related Classifications

Calculadora de molaridad
Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-183034863-56-1c-Met/HGFRATP competitivetype-III c-METWT/D1228V mutantc-MET driven cancersInhibitorinhibitorinhibit

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c-Met-IN-18

c-Met-IN-18 Related Antibodies

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Referencias

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c-Met-IN-18 Related Classifications

Calculadora de molaridad

Calculadora de dilución