55283-68-6
Chemical Structure
Ethalfluralin
- CAS No.: 55283-68-6
- Formula:C13H14F3N3O4
- Molecular Weight:333.26
IUPAC Name: N-ethyl-N-(2-methylallyl)-2,6-dinitro-4-(trifluoromethyl)aniline
InChIKey: PTFJIKYUEPWBMS-UHFFFAOYSA-N
SMILES: O=[N+]([O-])C1=C(N(CC)CC(C)=C)C([N+]([O-])=O)=CC(C(F)(F)F)=C1
Biological Activity: Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK, inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis, endoplasmic reticulum stress, autophagy, and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis[1][2][3].
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Ethalfluralin | Ethalfluralin is a dinitroaniline herbicide and microtubule inhibitor. Ethalfluralin blocks nuclear division and cytokinesis of parasites by inhibiting intranuclear spindle formation. Ethalfluralin activates the phosphorylation levels of NF-κB and P38 MAPK, inhibits the PI3K/AKT signaling pathway, impairs mitochondrial function, and induces apoptosis, endoplasmic reticulum stress, autophagy, and ROS production. Ethalfluralin is applicable to research related to toxoplasmosis. | |||||||||||||||||||||
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References
- [1]. Ham J, et al. Ethalfluralin impairs implantation by aggravation of mitochondrial viability and function during early pregnancy. Environ Pollut. 2022;307:119495. [Content Brief]
- [2]. Hong T, et al. Ethalfluralin induces developmental toxicity in zebrafish via oxidative stress and inflammation. Sci Total Environ. 2023;854:158780. [Content Brief]
- [3]. Stokkermans TJ, et al. Inhibition of Toxoplasma gondii replication by dinitroaniline herbicides. Exp Parasitol. 1996;84(3):355-370. [Content Brief]
