PDIA5 - protein disulfide isomerase family A member 5 Gene

Also Known as PDIR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10954

About PDIA5

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,067,025-123,162,104 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 13 paralogues. Ubiquitous expression in placenta (RPKM 25.8), prostate (RPKM 23.2) and 24 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. The N-terminal TRX-like domain is the primary binding site for the major ER chaperone calreticulin and possibly Other proteins and substrates as well. Alternative splicing results in multiple protein- and non-protein-coding transcript variants. [provided by RefSeq, Dec 2016]

PDIA5 Products (1)

mRNA Protein Name
NM_006810.4 NP_006801.1 protein disulfide-isomerase A5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein disulfide isomerase activity IDA
IDA: Inferred from direct assay
14627699 GOA
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
16677074 GOA
Biological Process GO Annotation Evidence References Source
involved in protein folding IDA
IDA: Inferred from direct assay
14627699 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIA5 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (156 - 257)

Thioredoxin

Thioredoxin: Thioredoxin (278 - 379)

Thioredoxin

Thioredoxin: Thioredoxin (399 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A5

  • protein disulfide isomerase-associated 5

PDIA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDIA5 Q14554 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
PDIA5 Q14554 MDFI Homo sapiens Q99750
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDIA5 Proteins

Cat. No. Product Name Accession Purity
HY-P71192 PDIA5 Protein, Human (HEK293, His) Q14554-2 (S22-L262) ≥ 90%, as determined by reducing SDS-PAGE.

PDIA5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810037 PDIR Antibody (YA9381) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10270 PDIA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19729 Pdia5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26225 Pdia5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDIA5 VGNC VGNC:64085
Macaca mulatta PDIA5 VGNC VGNC:75858
Rattus norvegicus PDIA5 RGD RGD:1359236
Canis familiaris PDIA5 VGNC VGNC:44378
Mus musculus PDIA5 MGD MGI:1919849
Bos taurus PDIA5 VGNC VGNC:32699
Others PDIA5 NCBI