Hnrnpa2b1 - heterogeneous nuclear ribonucleoprotein A2/B1 Gene

Also Known as Hnrpa2; hnrnp-A; Hnrpa2b1; 9130414A06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53379

Summary

Enables pre-mRNA intronic binding activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in inclusion body myopathy with Paget disease of bone and frontotemporal dementia and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2. Orthologous to human HNRNPA2B1 (heterogeneous nuclear ribonucleoprotein A2/B1). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpa2b1 Products (3)

mRNA Protein Name
NM_001374745.1 NP_001361674.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 3
NM_016806.3 NP_058086.2 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 1
NM_182650.4 NP_872591.1 heterogeneous nuclear ribonucleoproteins A2/B1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IPI
IPI: Inferred from physical interaction
23907535 MGI
enables pre-mRNA intronic binding IDA
IDA: Inferred from direct assay
18480465 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
18480465 MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
18480465 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
23907535 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17962088 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoproteins A2/B1

  • heterogenous nuclear ribonucleoprotein A2/B1

  • hnRNP A2/B1

Recombinant Hnrnpa2b1 Proteins

Cat. No. Product Name Accession Purity
HY-P72232 HNRNPA2B1 Protein, Mouse (His-SUMO, Myc) O88569 (M1-Y353) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N13009 MO-2097 / Unkown
HY-RS06262 HNRNPA2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18110 Hnrnpa2b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24584 Hnrnpa2b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnrnpa2b1 NCBI NCBI:3181