PLG - plasminogen Gene

Also Known as HAE4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5340

About PLG

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:160,702,193-160,754,097 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues, 14 paralogues and is associated with 4 phenotypes. Restricted expression toward liver (RPKM 588.1).

Summary

The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), Kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to Other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]

PLG Products (4)

mRNA	Protein	Name
NM_000301.5	NP_000292.1	plasminogen isoform 1 precursor
NM_001168338.1	NP_001161810.1	plasminogen isoform 2 precursor
NM_000301.5	NP_000292.1	plasminogen isoform 1 precursor
NM_001168338.1	NP_001161810.1	plasminogen isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	16480936	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	7679575	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12666133	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	24196407	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	7679575	GOA
enables protein antigen binding	IPI IPI: Inferred from physical interaction	17849409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	134998	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9786936	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	17307854	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	14688145	GOA
enables serine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	18070902	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	20028034	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in biological process involved in interaction with symbiont	IDA IDA: Inferred from direct assay	12818429	GOA
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	1986355	GOA
involved in extracellular matrix disassembly	IDA IDA: Inferred from direct assay	14699093	GOA
involved in fibrinolysis	IDA IDA: Inferred from direct assay	14688145	GOA
involved in negative regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	14699093	GOA
involved in negative regulation of fibrinolysis	IDA IDA: Inferred from direct assay	14726399	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	21106936	GOA
involved in positive regulation of fibrinolysis	IDA IDA: Inferred from direct assay	6438154	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	9603964	GOA
involved in proteolysis	IMP IMP: Inferred from mutant phenotype	18070902	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	14699093	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	14699093	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	6216475	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLG Protein Structure

PAN_1

Kringle

Trypsin

0
200
400
600
810 a.a.

Protein Preferred Names	Protein Names
plasminogen	plasmin

PLG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	PLG	P00747	skc	Streptococcus equisimilis	P00779	X-Ray Diffraction	12456874
Intra	PLG	P00747	APOH	Homo sapiens	P02749	ELISA	16480936
Cross	PLG	P00747	q6v4l9_strpy	Streptococcus pyogenes	Q6V4L9	Filter Binding	16319056
Cross	PLG	P00747	q6v4l1_strpy	Streptococcus pyogenes	Q6V4L1	Competition Binding	16319056
Cross	PLG	P00747	q6v4l1_strpy	Streptococcus pyogenes	Q6V4L1	Filter Binding	16319056
Cross	PLG	P00747	q6v4l4_strpy	Streptococcus pyogenes	Q6V4L4	Filter Binding	16319056
Cross	PLG	P00747	q6v4l4_strpy	Streptococcus pyogenes	Q6V4L4	Competition Binding	16319056
Cross	PLG	P00747	pdhC	Mycoplasma pneumoniae	P75392	Far-WB	25978044
Cross	PLG	P00747	pdhC	Mycoplasma pneumoniae	P75392	ELISA	25978044
Cross	PLG	P00747	pdhD	Mycoplasma pneumoniae	P75393	Far-WB	25978044
Cross	PLG	P00747	pdhD	Mycoplasma pneumoniae	P75393	ELISA	25978044
Cross	PLG	P00747	pdhB	Mycoplasma pneumoniae	P75391	ELISA	25978044
Cross	PLG	P00747	pdhB	Mycoplasma pneumoniae	P75391	Far-WB	25978044
Cross	PLG	P00747	pdhB	Mycoplasma pneumoniae	P75391	ELISA	23197176
Cross	PLG	P00747	pdhA	Mycoplasma pneumoniae	P75390	ELISA	25978044
Cross	PLG	P00747	pdhA	Mycoplasma pneumoniae	P75390	Far-WB	25978044
Cross	PLG	P00747	sak	Staphylococcus aureus	Q99SU7	SPR	22321644
Cross	PLG	P00747	sak	Staphylococcus aureus	Q99SU7	Enzymatic Study	22321644

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71939	Plasminogen Protein, Human	P00747 (V98-P356)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Plasminogen Deficiency, Type I	Hypoplasminogenemia Dysplasminogenemia Plasminogen Deficiency Type I Congenital Plasminogen Deficiency Ligneous Conjunctivitis Type 1 Plasminogen Deficiency Plasminogen Deficiency Type 1 Plasminogen Deficiency PLGD Plasminogen Deficiency Type Ii Deficiency, Plasminogen, Type I
Angioedema, Hereditary, 4	HAE4
Plg-Related Hereditary Angioedema With Normal C1inh	Plg-Related Hae With Normal C1 Inhibitor
Hereditary Angioedema	Hereditary Angioneurotic Edema Hereditary Angioedema Type 1 Hane Angioedema, Hereditary Hae Angioedemas, Hereditary Deficiency Of C1 Esterase Inhibitor C1 Esterase Inhibitor Deficiency C1 Inhibitor Deficiency Familial Angioneurotic Edema Hereditary Bradykinine-Induced Angioedema Hereditary Non Histamine-Induced Angioedema Hae 1 Hae-I Hereditary Angioneurotic Edema Type 1 Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii Hereditary Angioneurotic Oedema Familial Angioedema Hae - [Hereditary Angioneurotic Oedema] Bannister Disease, Hereditary Quincke Disease Or Oedema Hereditary Quincke Oedema
Angioedema, Hereditary, 1	Hereditary Angioedema Type I Hereditary Angioneurotic Edema Hane C1 Esterase Inhibitor Deficiency Angioedema, Hereditary, 1 And 2 HAE1 Angioneurotic Edema, Hereditary Angioedema, Hereditary, Type I Hereditary Angioedema Type 2 Hae 2 Hae-Ii Hereditary Angioneurotic Edema Type 2 Angioedema, Hereditary HAE Angioedema, Hereditary, Types I And Ii Hereditary Angioedema, Type Ii Angioedema, Hereditary, Type 1 Angioedemas, Hereditary Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii
Ligneous Conjunctivitis	Conjunctivitis Lignosa Conjunctivitis, Ligneous
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Thrombosis	Thrombosis Of Blood Vessel
Corneal Neovascularization	Corneal Neovascularisation Corneal Vascularisation Extensive Superficial Corneal Vascularisation
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Intracranial Embolism	Cerebral Embolism Cerebral Embolism With Cerebral Infarction
Hepatic Veno-Occlusive Disease	Veno-Occlusive Disease Sinusoidal Obstruction Syndrome Hepatic Venoocclusive Disease Venoocclusive Disease Hepatic Vein Thrombosis Budd-Chiari Syndrome Hepatic Vein Occlusion Veno-Occlusive Disease Of The Liver
Brain Stem Infarction	Brain Stem Infarctions Brainstem Infarction
Basilar Artery Occlusion
Alveolar Periostitis	Dry Socket Alveolitis Of Jaw Dry Tooth Socket Alveolar Pyorrhea Alveolar Osteitis Alveolitis Sicca Dolorosa Alveolodental Periostitis
Hemangioendothelioma
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Basilar Artery Insufficiency	Basilar Artery Syndrome
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Central Retinal Artery Occlusion
Cerebral Artery Occlusion
Pneumonic Plague	Primary Pneumonic Plague Secondary Pneumonic Plague Plague Plague, Pneumonic Plague Pneumonia Plague Of Lung Pulmonary Plague Pneumonia Due To Yersinia Pestis
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Middle Cerebral Artery Infarction	Infarction, Middle Cerebral Artery Infarction Middle Cerebral Artery
Post-Thrombotic Syndrome	Postphlebitic Syndrome Postthrombotic Syndrome Postphlebetic Syndrome With Inflammation Postphlebetic Syndrome With Ulcer Postphlebetic Syndrome With Ulcer And Inflammation Venous Stress Disorder
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Septicemic Plague	Plague, Septicemic
Vertebral Artery Occlusion	Occlusion And Stenosis Of Vertebral Artery
Retinal Vascular Disease	Retinal Vascular Retinal Vascular Disorder Retina Circulation Disorder
Disseminated Intravascular Coagulation	Defibrination Syndrome Dic Diffuse Or Disseminated Intravascular Coagulation Fibrinolytic Purpura Consumption Coagulopathy Diffuse Intravascular Coagulation Dic - [Disseminated Intravascular Coagulation] Disseminated Intravascular Coagulopathy Fibrinolysis Nos Thrombolytic Purpura
Livedoid Vasculitis	Livedoid Vasculopathy Livedo Reticularis With Summer Ulcerations Livedo Vasculitis Livedo Reticularis With Winter Ulcerations Segmental Hyalinizing Vasculopathy Milian Atrophie Blanche Segmental Hyalinizing Vasculitis Livedo Reticularis With Summer Ulceration
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Thrombophilia Due To Activated Protein C Resistance	Activated Protein C Resistance Apc Resistance THPH2 Thrombophilia Due To Deficiency Of Activated Protein C Cofactor Proc Cofactor Deficiency Pccf Deficiency Thrombophilia V Thrombophilia, Susceptibility To, Due To Factor V Leiden Thrombophilia Due To Factor V Leiden Thrombophilia 2 Due To Activated Protein C Resistance Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance
Inferior Myocardial Infarction	Inferior Wall Myocardial Infarction
Posterior Cerebral Artery Infarction	Infarction, Posterior Cerebral Artery
Alpha-2-Plasmin Inhibitor Deficiency	Plasmin Inhibitor Deficiency Antiplasmin Deficiency Antiplasmin Defiency Anti-Plasmin Deficiency, Congenital Antiplasmin Deficiency, Congenital Congenital Alpha2-Antiplasmin Deficiency APLID Congenital Alpha2 Antiplasmin Deficiency
Anterior Cerebral Artery Infarction	Infarction, Anterior Cerebral Artery
Retinal Vascular Occlusion	Retinal Vasc. Occlusion Occlusion Of Retinal Vessels Retinal Obstruction
Basal Ganglia Cerebrovascular Disease
Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome Haemolytic-Uraemic Syndrome Hus Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes Typical Haemolytic Uraemic Syndrome Gasser Syndrome Hus - [Haemolytic Uraemic Syndrome]
Lateral Medullary Syndrome	Posterior Inferior Cerebellar Artery Syndrome Wallenberg Syndrome Vertebral Artery Syndrome Wallenberg'S Syndrome Pica Syndrome
Pseudomembranous Conjunctivitis
Brown-Sequard Syndrome	Brown-Squard Syndrome Hemicord Syndrome Hemiparaplegic Syndrome Hemispinal Cord Syndrome Brown-Séquard Syndrome
Thoracic Outlet Syndrome	Tos Tos - Thoracic Outlet Syndrome Thoracic Outlet Syndromes Thoracic Outlet Compression Syndrome
Gynatresia
Vitreous Detachment	Posterior Vitreous Detachment Vitreous Syneresis
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Conversion Disorder	Conversion Hysteria Or Reaction Conversion Hysterical Neurosis Hysterical Neurosis, Conversion Type Fnd Functional Movement Disorder Functional Neurological Disorder Dissociative Disorder
Vein Disease	Disorder Of Vein
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Hemopericardium	Haemopericardium Pericardial Effusion Haematopericardium Pneumohemopericardium Pericardium Haemorrhage Haemorrhagic Pericarditis
Leech Infestation	Hirudiniasis Leeches
Branch Retinal Artery Occlusion	Retinal Artery Occlusion Arterial Retinal Branch Occlusion Retinal Arterial Branch Occlusion
Vertebrobasilar Insufficiency	Vertebro-Basilar Insufficiency Vertebrobasilar Arterial Insufficiency Vertebrobasilar Artery Syndrome
Vascular Cancer	Blood Vessel Tumors Malignant Vascular Neoplasm Renal Vein Leiomyosarcoma Vascular Neoplasms Blood Vessel Neoplasm Blood Vessel Tumor Blood Vessel Tumour Disorder Haemangiomatous Tumour Leiomyosarcoma Of The Renal Vein Malignant Great Vessel Tumor Malignant Tumor Of Pulmonary Artery Malignant Tumor Of Pulmonary Vein Malignant Vascular Tumor Neoplasm Of Great Vessel Pulmonary Artery Malignant Neoplasm Pulmonary Vein Malignant Neoplasm Vascular Tissue Neoplasm Vascular Tumors Blood Vessel Cancer Neoplasms, Vascular Tissue Malignant Neoplasm Of Great Vessels
Central Retinal Vein Occlusion	Crvo
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Secondary Hyperparathyroidism Of Renal Origin	Hyperparathyroidism Due To Renal Insufficiency Hyperparathyroidism, Secondary
Intracranial Thrombosis	Cerebral Thrombosis Thrombosis Of Cerebral Veins Cerebral Arterial Thrombosis
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Sagittal Sinus Thrombosis	Thrombosis Of Superior Longitudinal Sinus Thrombosis Of Superior Sagittal Sinus Thrombosis Superior Sagittal Sinus
Acute Anterolateral Myocardial Infarction	Acute Myocardial Infarction Of Anterolateral Wall
Nonbacterial Thrombotic Endocarditis	Non-Bacterial Thrombotic Endocarditis Marantic Endocarditis Non-Infective Endocarditis
Acute Cor Pulmonale
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies	Familial Encephalopathy With Neuroserpin Inclusion Bodies FENIB Encephalopathy, Familial, With Collins Bodies Familial Dementia With Neuroserpin Inclusion Bodies Familial Encephalopathy With Collins Bodies
Ischemia	Acute Coronary Syndrome
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Pleural Empyema	Empyema Pyothorax Empyema, Pleural Abscess Of Pleural Cavity Abscess Of Thorax Empyema Of Pleura Empyema Of Pleura Without Fistula Empyema With Fistula Empyema With No Fistula Empyema With Pleural Fistula Empyema Without Mention Of Fistula Empyema, Chest Lung Empyema Pleural Empyema With Fistula Pleural Empyema With No Fistula Purulent Pleurisy Purulent Pleuritis Thorax Abscess Pyopneumothorax
Antithrombin Iii Deficiency	Hereditary Antithrombin Deficiency Congenital Antithrombin Iii Deficiency Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency AT3D Thrombophilia Due To Antithrombin Iii Deficiency Thph7 Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency Thrombophilia 7 Due To Antithrombin Iii Deficiency At Iii Deficiency Congenital At-Iii Deficiency Inherited Antithrombin Deficiency Antithrombin 3 Deficiency Antithrombin Deficiency Antithrombin-Iii Deficiency At-Iii Deficiency Thrombophilia Due To Antithrombin-Iii Deficiency
Heparin Cofactor Ii Deficiency	Thrombophilia Due To Heparin Cofactor Ii Deficiency THPH10 Hcf Ii Deficiency Hcf2 Deficiency Thrombophilia 10 Due To Heparin Cofactor Ii Deficiency Hcf 2 Deficiency Thrombophilia Due To Heparin Cofactor 2 Deficiency Thrombophilia, Due To Heparin Cofactor Ii Deficiency
Intracranial Sinus Thrombosis	Sinus Thrombosis, Intracranial
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Acute Pulmonary Heart Disease
Chronic Venous Insufficiency
Rubeosis Iridis
Anteroseptal Myocardial Infarction
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Cholesterol Embolism	Atheroembolism Trash Foot Cholesterol Crystal Embolism Purple Toe Syndrome Warfarin Blue Toe Syndrome Embolism, Cholesterol Cholesterol Embolus Syndrome
Coronary Thrombosis	Coronary Artery Thrombosis
Cerebral Arterial Disease	Cerebral Arterial Diseases
Locked-In Syndrome	Locked In Syndrome Cerebromedullospinal Disconnection Locked-In State Quadriplegia
Purpura Fulminans	Purpura Gangrenosa
Quebec Platelet Disorder	Factor V Quebec QPD Bdplt5 Bleeding Disorder, Platelet-Type, 5 Platelet-Type Bleeding Disorder 5 Bleeding Disorder Platelet-Type 5 Platelet Disorder, Quebec
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Compartment Syndrome	Compartment Syndromes Compartmental Syndrome
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Pulmonary Artery Leiomyosarcoma	Leiomyosarcoma Of The Pulmonary Artery
Retinal Artery Occlusion	Retina Artery Narrowing Retinal Artery Spasm Spasm Of Ophthalmic Artery Retinal Spasm Vasospasm Of Retina
Necrotizing Fasciitis	Fasciitis, Necrotizing
Carotid Artery Dissection	Dissection Of Carotid Artery
Anterior Spinal Artery Syndrome	Anterior Spinal Artery Occlusion Syndrome
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Dysbaric Osteonecrosis	Caisson Disease Of Bone Don
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Thrombophlebitis	Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities Superficial Thrombophlebitis Of Leg Thrombophlebitis Of A Superficial Leg Vein Thrombophlebitis Of Superficial Veins Of Lower Extremity
Portal Vein Thrombosis	Phlebitis Of Portal Vein Deep Vein Thrombosis Of Portal Vein Portal Thrombosis Pvt - [Portal Vein Thrombosis] Portal Venous Thrombosis Portal Venous Embolism Portal Venous Obstruction Portal Venous Block Portal Vein Embolism Portal Vein Block Portal Obstruction Portal Embolism Portal Block Hepatic Portal Vein Obstruction Occlusion Of Hepatic Portal Vein Portal Vein Obstruction
Endocardium Disease
Neovascular Glaucoma	Glaucoma, Neovascular Secondary Angle-Closure Glaucoma With Rubeosis Glaucoma Neovascular
Infective Endocarditis	Bacterial Endocarditis Endocarditis, Infective Infectious Endocarditis Endocarditis Infective
Carotid Artery Thrombosis
Lemierre'S Syndrome	Lemierre Syndrome Lemierre Postanginal Sepsis Necrobacillosis Postanginal Sepsis Secondary To Orophyngeal Infection Septic Phlebitis Of The Internal Jugular Vein Fusobacterium Infections Acute Sore Throat Human Necrobacillosis Postanginal Sepsis Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein
Erysipeloid	Infection Due To Erysipelothrix Rhusiopathiae Erysipelothrix Infection
Moyamoya Disease 1	Moyamoya Disease Spontaneous Occlusion Of The Circle Of Willis Mymy Progressive Intracranial Arterial Occlusion Moyamoya Syndrome MYMY1 Cerebrovascular Moyamoya Disease Moya-Moya Disease Progressive Intracranial Occlusive Arteropathy Idiopathic Moyamoya Disease
Medulloadrenal Hyperfunction
Vitreous Disease	Disorder Of Vitreous Body
Acute Poststreptococcal Glomerulonephritis	Post-Streptococcal Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Kuhnt-Junius Degeneration	Neovascular Age-Related Macular Degeneration Exudative Senile Macular Degeneration Of Retina Senile Macular Degeneration, Wet Wet Senile Macular Retinal Degeneration Exudative Age-Related Macular Degeneration Exudative Macular Degeneration
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Hepatic Vascular Disease	Vascular Disorder Of Liver
Aphasia
Hemiplegia	Infantile Hemiplegia Postnatal Infantile Hemiplegia Hemiplegia, Infantile
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Limb Ischemia
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Anosognosia
Cardiac Tamponade	Pericardial Tamponade Rose'S Tamponade
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Macular Holes	Macular Hole
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Facial Paralysis	Facial Palsy Bell Palsy
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Facial Nerve Disease	Facial Nerve Disorder Facial Nerve Diseases Neuropathy Of Facial Nerve Disorders Of 7th Cranial Nerve Disorders Of The Seventh Cranial Nerve
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Retinal Perforation	Retinal Break Retinal Perforations Retinal Dialysis Retinal Tear Retinal Break Nos Ruptured Retina
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Mitral Valve Stenosis	Mitral Stenosis Rheumatic Mitral Stenosis Ms - [Mitral Stenosis] Mitral Valvular Stricture Mitral Valve Stricture Mitral Stricture Chronic Mitral Stenosis Mitral Obstruction Mitral Valve Obstruction Mitral Stenosis With Incompetence Mitral Stenosis With Regurgitation Rheumatic Mitral Insufficiency With Obstruction
Obstructive Hydrocephalus
Endophthalmitis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Central Nervous System Origin Vertigo	Vertigo Of Central Origin Vertigo Central Vestibular Vertigo
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Conjunctival Disease	Conjunctival Diseases Conjunctival Disorder
Intracranial Hypertension	Raised Intracranial Pressure
Autoimmune Disease Of Cardiovascular System
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Premature Ovarian Failure 19	POF19 Primary Ovarian Insufficiency 19 Poi19 Ovarian Failure, Premature, Type 19
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Aortic Dissection
Barre-Lieou Syndrome	Cervicocranial Syndrome Posterior Cervical Sympathetic Syndrome
Atrial Heart Septal Defect	Atrial Septal Defect Atrial Septal Defects Atrioseptal Defect Auricular Septal Defect Congenital Atrial Septal Defect Interatrial Septal Defect Interauricular Septal Defect Heart Septal Defects, Atrial Septal Defect, Atrial
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Arteries, Anomalies Of	Artery Disease Arteriopathic Disease
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Acquired Color Blindness	Acquired Color Vision Deficiencies Acquired Color Vision Deficiency Acquired Colour Blindness Acquired Colour Vision Deficiencies Acquired Colour Vision Deficiency
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103423	PAOPA	Modulator	98.09%	Unkown
HY-RS10704	PLG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16986	Plg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23429	Plg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991895	PLG-101	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PLG	VGNC	VGNC:110549
Felis catus	PLG	VGNC	VGNC:102484
Rattus norvegicus	PLG	RGD	RGD:619893
Mus musculus	PLG	MGD	MGI:97620
Macaca mulatta	PLG	VGNC	VGNC:82206
Others	PLG	NCBI