Synthesis and biological evaluation of a new vitamin D2 analogue

  • Bioorg Med Chem Lett. 2012 Oct 1;22(19):6276-9. doi: 10.1016/j.bmcl.2012.07.095.
Zoila Gándara  1 ,  Manuel Pérez ,  Débora G Salomón ,  María J Ferronato ,  María E Fermento ,  Alejandro C Curino ,  María M Facchinetti ,  Generosa Gómez ,  Yagamare Fall
Affiliations
  • 1. Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, 36200 Vigo, Spain.
PMID: 22926068 DOI: 10.1016/j.bmcl.2012.07.095
Abstract

A new vitamin D(2) analogue was synthesized using the Julia-Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas of colon and head and neck, but is also as hypercalcaemic as calcitriol in vivo.