Pedunculagin and tellimagrandin-I stimulate inflammation and angiogenesis and upregulate vascular endothelial growth factor and tumor necrosis factor-alpha in vivo

  • Microvasc Res. 2024 Jan:151:104615. doi: 10.1016/j.mvr.2023.104615.
Amanda Silva Fernandes  1 ,  Abel Vieira de Melo Bisneto  1 ,  Luana Santos Silva  1 ,  Elisa Flávia Luiz Cardoso Bailão  2 ,  Clever Gomes Cardoso  1 ,  Cristiene Costa Carneiro  1 ,  Suzana da Costa Santos  3 ,  Lee Chen-Chen  4
Affiliations
  • 1. Laboratory of Radiobiology and Mutagenesis, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, Brazil.
  • 2. Laboratory of Biotechnology, Henrique Santillo Campus, State University of Goiás, Anápolis, Goiás, Brazil.
  • 3. Chemistry Institute, Federal University of Goiás, Goiânia, Goiás, Brazil.
  • 4. Laboratory of Radiobiology and Mutagenesis, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Goiás, Brazil. Electronic address: [email protected].
PMID: 37797833 DOI: 10.1016/j.mvr.2023.104615
Abstract

Pedunculagin (PD) and tellimagrandin-I (TL), isolated from Myrciaria cauliflora seeds and Eucaliptus microcorys leaves, respectively, have attracted great attention owing to their relevant biological activities, such as antitumor, antioxidant, and hepatoprotective activities. This study investigated the angiogenic potential of PD and TL using a chick embryo chorioallantoic membrane (CAM) assay. Using the CAM assay, our results showed that both PD and TL promoted a significant increase in the number and caliber of blood vessels, the thickness of the CAM, and the presence of fibroblasts and inflammatory cells. Moreover, an increase of tumor necrosis factor-α and vascular endothelial growth factor was observed in the CAM treated with PD and TL, indicating the induction of angiogenic factors. Thus, the remarkable profile of PD and TL in inducing angiogenesis opens up new perspectives for their potential utilization in different therapeutic approaches involving neovascularization.

Keywords
Angiogenesis; Hydrolyzable tannin; Inflammatory cells; Pedunculagin, tellimagrandin-I; VEGF.
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