3056077-07-4
Chemical Structure
ERK1/2 inhibitor 10
- CAS No.: 3056077-07-4
- Formula:C23H20ClN5O2S
- Molecular Weight:465.96
InChIKey: KJXLOFYRZSSMJF-LJQANCHMSA-N
SMILES: O=C(C1=CC(C2=NC(NC3=CC=NC(C)=C3)=NC=C2Cl)=CS1)N[C@@H](C4=CC=CC=C4)CO
Biological Activity: ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC50: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations[1].
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ERK1/2 inhibitor 10 | ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC50: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations. | |||||||||||||||||||||
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