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Cat. No.: HY-149641

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CDK9-IN-29

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC₅₀ = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis.

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CAS No.: 2737262-24-5
Formule: C₂₉H₃₃F₂N₅O₄
Masse moléculaire:553.60

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CDK9-IN-29 Chemical Structure

CAS No.: 2737262-24-5

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC₅₀ = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.409 μM Compound: Z11	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
HCC827	IC₅₀	0.315 μM Compound: Z11	Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1299	IC₅₀	0.085 μM Compound: Z11	Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1299 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	<0.05 μM Compound: Z11	Antiproliferative activity against 3D-cultured human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay Antiproliferative activity against 3D-cultured human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.083 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs in presence of osimertinib by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs in presence of osimertinib by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.174 μM Compound: Z11	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.19 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H1975	IC₅₀	0.251 μM Compound: Z11	Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay Antiproliferative activity against human Osimertinib-resistant NCI-H1975 cell incubated for 72 hrs by MTT assay	[PMID: 37870244]
NCI-H596	IC₅₀	0.332 μM Compound: Z11	Antiproliferative activity against human NCI-H596 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H596 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]
PC-9	IC₅₀	0.126 μM Compound: Z11	Antiproliferative activity against human PC-9 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human PC-9 cells incubated for 72 hrs by MTT assay	[PMID: 37870244]

Chemical Information

CAS No. 2737262-24-5
Masse moléculaire 553.60
Formule C₂₉H₃₃F₂N₅O₄
SMILES

FC1=C(C=C(C=C1)C2=C(C=NC(N3)=N2)F)OCCCCCCOC4=CC3=CC=C4C(NCCN5CCOCC5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tizhi Wu, et al. Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2023. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CDK9-IN-29

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CDK9-IN-29 Related Classifications

HY-149641 Related Classifications