RAP1GDS1 - Rap1 GTPase-GDP dissociation stimulator 1 Gene

Also Known as GDS1; SmgGDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5910

About RAP1GDS1

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:98,261,384-98,443,858 (from NCBI)

This gene has 21 transcripts (splice variants), 207 orthologues and is associated with 64 phenotypes. Ubiquitous expression in brain (RPKM 27.0), testis (RPKM 10.3) and 25 other tissues.

Summary

The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]

RAP1GDS1 Products (6)

mRNA	Protein	Name
NM_001100426.2	NP_001093896.1	rap1 GTPase-GDP dissociation stimulator 1 isoform 1
NM_001100427.2	NP_001093897.1	rap1 GTPase-GDP dissociation stimulator 1 isoform 3
NM_001100428.2	NP_001093898.1	rap1 GTPase-GDP dissociation stimulator 1 isoform 4
NM_001100429.2	NP_001093899.1	rap1 GTPase-GDP dissociation stimulator 1 isoform 5
NM_001100430.2	NP_001093900.1	rap1 GTPase-GDP dissociation stimulator 1 isoform 6
NM_021159.5	NP_066982.3	rap1 GTPase-GDP dissociation stimulator 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	21242305	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in CAAX-box protein maturation	IMP IMP: Inferred from mutant phenotype	20709748	GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24349085	GOA
involved in positive regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24349085	GOA
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	12551911	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	27716788	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytosol	IDA IDA: Inferred from direct assay	24349085	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24349085	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24349085	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12551911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1GDS1 Protein Structure

Arm

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607 a.a.

Protein Preferred Names	Protein Names
rap1 GTPase-GDP dissociation stimulator 1	RAP1, GTP-GDP dissociation stimulator 1

RAP1GDS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Cross	RAP1GDS1	P52306	P0DTD1-PRO_0000449620	SARS-CoV-2	P0DTD1-PRO_0000449620	BLI	34159380
Cross	RAP1GDS1	P52306	P0DTD1-PRO_0000449620	SARS-CoV-2	P0DTD1-PRO_0000449620	Y2H Array	36217030
Intra	RAP1GDS1	P52306	RAC1	Homo sapiens	P63000	Y2H Pooling	20936779
Intra	RAP1GDS1	P52306	PLEKHB1	Homo sapiens	Q9UF11	Anti Tag CoIP	33961781
Intra	RAP1GDS1	P52306	PLEKHB1	Homo sapiens	Q9UF11	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS11656	RAP1GDS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAP1GDS1	VGNC	VGNC:76659
Bos taurus	RAP1GDS1	VGNC	VGNC:33718
Mus musculus	RAP1GDS1	MGD	MGI:2385189
Rattus norvegicus	RAP1GDS1	RGD	RGD:1308558
Canis familiaris	RAP1GDS1	VGNC	VGNC:45343
Felis catus	RAP1GDS1	VGNC	VGNC:69237
Others	RAP1GDS1	NCBI