NADK - NAD kinase Gene

Also Known as dJ283E3.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65220

About NADK

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,751,232-1,780,514 (from NCBI)

This gene has 17 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in bone marrow (RPKM 24.4), spleen (RPKM 23.0) and 25 other tissues.

Summary

NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]

NADK Products (6)

mRNA Protein Name
NM_001198993.2 NP_001185922.1 NAD kinase isoform 1
NM_001198994.2 NP_001185923.1 NAD kinase isoform 2
NM_001198995.1 NP_001185924.1 NAD kinase isoform 3
NM_001353641.2 NP_001340570.1 NAD kinase isoform 1
NM_001353642.2 NP_001340571.1 NAD kinase isoform 4
NM_023018.5 NP_075394.3 NAD kinase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables NAD+ kinase activity IDA
IDA: Inferred from direct assay
11594753 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NADK Protein Structure

NAD_kinase

NAD_kinase: ATP-NAD kinase (134 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

NAD kinase

  • poly(P)/ATP NAD kinase

NADK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NADK O95544 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra
NADK O95544 CRY2 Homo sapiens Q49AN0
Validated Y2H
32296183
Intra
NADK O95544 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
NADK O95544 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
NADK O95544 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
NADK O95544 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
NADK O95544 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
NADK O95544 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NADK Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70141 NAD kinase/NADK Protein, Human (His) O95544-1 (S64-G446) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09004 NADK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09005 NADK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-151936 LmNADK1-IN-1 Inhibitor / Unkown
HY-RS18251 Nadk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24731 Nadk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NADK VGNC VGNC:75047
Bos taurus NADK VGNC VGNC:31863
Felis catus NADK VGNC VGNC:80288
Canis familiaris NADK VGNC VGNC:43605
Mus musculus NADK MGD MGI:2183149
Rattus norvegicus NADK RGD RGD:1642420
Others NADK NCBI