Peucedanol
Peucedanol is a non-competitive inhibitor of CYP3A4 with a Ki value of 4.07 μM and a competitive inhibitor of CYP1A2 and CYP2D6 with Ki values of 3.39 μM and 6.77 μM, respectively.
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- CAS No.: 46992-81-8
- Formule: C14H16O5
- Masse moléculaire:264.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Peucedanol (0, 2.5, 5, 10, 25, 50, and 100 μM; 0-30 min) is incubated with eight human liver CYP isoforms (CYP1A2, 2A6, 3A4, 2C8, 2C9, 2C19, 2D6, and 2E1), in pooled human liver microsomes (HLMs) for 30 min with specific inhibitors as positive controls.Peucedanol significantly inhibits the activity of CYP1A2, 2D6, and 3A4 in a dose-dependent manner with IC50 values of 6.03 μM, 13.57 μM, and 7.58 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 46992-81-8
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Masse moléculaire 264.27
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Formule C14H16O5
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SMILES
O=C1OC2=C(C=C1)C=C(CC(C(C)(C)O)O)C(O)=C2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Peucedanol Related Classifications
HY-N3090 Related Classifications
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