Chemical constituents of Brazilian Propolis from the state of Bahia and their growth inhibitory activities against cancer cells

  • Biosci Biotechnol Biochem. 2018 Mar;82(3):417-421. doi: 10.1080/09168451.2018.1427550.
Taichi Mitsui  1 ,  Sho Hotta  1 ,  Shigemi Tazawa  1 ,  Yasuko Arai  1 ,  Kenji Kato  1 ,  Kenji Ichihara  1
Affiliations
  • 1. a Nagaragawa Research Center, Api Co. Ltd. , Gifu , Japan.
PMID: 29370717 DOI: 10.1080/09168451.2018.1427550
Abstract

A novel 2-phenoxychromone (1) and five known Flavones (2-6) were isolated from northeastern Brazilian propolis in the state of Bahia. The chemical structures of these six compounds were determined by spectroscopic investigations and single-crystal X-ray analysis. The isolated compounds showed growth-inhibitory activities, in varying degrees, against human tumor cell lines. This is the first report on the discovery of a novel 2-phenoxychromone from propolis.

Keywords
2-Phenoxychromone; Bahia state; Brazilian propolis; anti-cancer.
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