Thienodolin
Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 149127-27-5
- Formule: C11H7ClN2OS
- Masse moléculaire:250.70
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Thienodolin (6.25-50 μM, 15 min pretreatment) inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 cells (IC50 = 17.2 μM)[1].
Thienodolin (6.25-50 μM, 5-18 h) suppresses iNOS expression in a dose-dependent manner at both mRNA and protein levels in LPS-stimulated RAW 264.7 cells[1].
Thienodolin (6.25-50 μM, 15 min pretreatment) blocks the degradation of IκBα, reduces the phosphorylation level of STAT1 at Tyr701 and attenuates NF-κB p65 accumulation in the nucleus in LPS-stimulated RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LPS-stimulated RAW 264.7 cells
-
Concentration:6.25, 12.5, 25, 50 μM
-
Incubation Time:15 min pretreatment
-
Result:Blocked the degradation of IκBα.
Reduced the phosphorylation level of STAT1 at Tyr701.
Attenuated NF-κB p65 accumulation in the nucleus.
Chemical Information
-
CAS No. 149127-27-5
-
Masse moléculaire 250.70
-
Formule C11H7ClN2OS
-
SMILES
O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
-
Synonyms
MJ 286A
-
Structure Classification
-
Initial Source
Streptomyces albogriseolus
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thienodolin Related Classifications
HY-N16376 Related Classifications
Powered by Bioz