(Z)-Isbogrel
(Z)-Isbogrel ((Z)-CV-4151) is a potent thromboxane A2 (TxA2) synthase inhibitor with an IC50 of 0.9 nM. (Z)-Isbogrel inhibits serum TxB2 production, with an ED50 of 0.01 mg/kg upon intravenous administration and an ED50 of 0.05 mg/kg upon oral administration in rats, and it exhibits no PAF receptor antagonistic activity. (Z)-Isbogrel can be used in research related to cardiovascular and cerebrovascular diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 89667-39-0
- Formule: C18H19NO2
- Masse moléculaire:281.36
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
TXA2 0.9 nM (IC50) |
(Z)-Isbogrel potently inhibits thromboxane A2 synthase activity in human platelet microsomes. When TxB2 production is measured using PGH2 as the substrate, the IC50 value is 0.9 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 89667-39-0
-
Masse moléculaire 281.36
-
Formule C18H19NO2
-
SMILES
C(=C/CCCCC(O)=O)(\C1=CC=CC=C1)/C=2C=CC=NC2
-
Synonyms
(Z)-CV-4151
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Z)-Isbogrel Related Classifications
HY-119890A Related Classifications
Powered by Bioz