1005178-02-8
Chemical Structure
TI17
- CAS No.: 1005178-02-8
- Formula:C23H22N2O3
- Molecular Weight:374.43
IUPAC Name: 7-((4-(pyridin-4-ylmethyl)phenyl)carbamoyl)tricyclo[3.2.2.02,4]non-8-ene-6-carboxylic acid
InChIKey: FTGODPNMSWLLKK-UHFFFAOYSA-N
SMILES: OC(C1C2C=CC(C1C(NC3=CC=C(C=C3)CC4=CC=NC=C4)=O)C5CC25)=O
Biological Activity: TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].
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TI17 | 95.97% | TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage. | ||||||||||||||||||||
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Keywords
