1009821-64-0
Chemical Structure
CX-5279 free acid
- CAS No.: 1009821-64-0
- Formula:C22H16F3N5O2
- Molecular Weight:439.39
InChIKey: UXZATHOFDZQOMY-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=NC(NC3=CC=CC(C(F)(F)F)=C3)=C4N=C(NC5CC5)N=CC4=C2C=C1)O
Biological Activity: CX-5279 free acid is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 free acid is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279 free acid's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 free acid exhibits anti-proliferative activity in various cancer cell lines. CX-5279 free acid can be used for research on cancers such as pancreatic cancer and leukemia[1].
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CX-5279 free acid | CX-5279 free acid is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 free acid is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279 free acid's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 free acid exhibits anti-proliferative activity in various cancer cell lines. CX-5279 free acid can be used for research on cancers such as pancreatic cancer and leukemia. | |||||||||||||||||||||
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Keywords
